| Peer-Reviewed

The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study

Received: 7 October 2020     Accepted: 22 October 2020     Published: 30 October 2020
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Abstract

Use of dietary supplements like multivitamins/multiminerals (MVMM) and antioxidant nutrients, is a potentially safe and cost-effective alternative to medications. Dietary supplements-induced health promotion is controversial among available studies, and vast majority studies were done with individual or a subset of dietary supplements. In this study we assessed the effect of a blended supplement (CellSentials), formulated with MVMM and rich phytochemicals antioxidants, on multiple cardio-metabolic risk biomarkers. We recruited 56 subjects (age: 58.8 ± 1.6) with over one year consumption of blended supplements. Common cardio-metabolic risk biomarkers were measured, including systolic and diastolic blood pressure (SBP and DBP), plasma glucose (Glu), total cholesterol (TC), triglycerides (TGs), high-density cholesterol (HDL-C)), low-density cholesterol (LDL-C), TC: HDL ratio, oxidative stress markers gamma-glutamyltransferase (GGT), and inflammation markers white blood cell (WBC) count, and C-reactive protein (CRP). They were compared to the age, gender and race-matched Non-Users from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 (n=769, mean age: 55.6 ± 0.5) by multiple linear and logistic regression analyses. Blended supplements users had significantly lower levels of Glucose (p< 0.001), TGs (p<0.001), and TC: HDL-C ratio (p<0.001), higher level of HDL-C (p=0.008) as well as lower levels of GGT (p=0.002), CRP (p=0.007) and WBC (p=0.002) than NHANES controls. There were no significant differences in SBP, DBP, TC, LDL-C. Correspondingly, blended supplements users had significantly reduced risks of elevated glucose (OR, 0.21; 95% CI, 0.07 – 0.61), ratio of TC: HDL-C (OR, 0.08; 95% CI, 0.02 – 0.31), TGs levels (OR, 0.07; 95% CI, 0.01 – 0.4), and low HDL-C (OR, 0.23; 95%CI, 0.06 – 0.88). These results demonstrated that blended supplement users had healthier pattern in cardio-metabolic biomarkers than control.

Published in Journal of Food and Nutrition Sciences (Volume 8, Issue 5)
DOI 10.11648/j.jfns.20200805.12
Page(s) 127-138
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Cardio-Metabolic Risk Biomarkers, Oxidative Stress, Inflammation, MVMMs, Antioxidant Nutrients, NHANES, Multiple Regression

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    Huifeng Jin, Rolando Lorenzo Maddela, Robert Andrew Sinnott. (2020). The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study. Journal of Food and Nutrition Sciences, 8(5), 127-138. https://doi.org/10.11648/j.jfns.20200805.12

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    ACS Style

    Huifeng Jin; Rolando Lorenzo Maddela; Robert Andrew Sinnott. The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study. J. Food Nutr. Sci. 2020, 8(5), 127-138. doi: 10.11648/j.jfns.20200805.12

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    AMA Style

    Huifeng Jin, Rolando Lorenzo Maddela, Robert Andrew Sinnott. The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study. J Food Nutr Sci. 2020;8(5):127-138. doi: 10.11648/j.jfns.20200805.12

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  • @article{10.11648/j.jfns.20200805.12,
      author = {Huifeng Jin and Rolando Lorenzo Maddela and Robert Andrew Sinnott},
      title = {The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study},
      journal = {Journal of Food and Nutrition Sciences},
      volume = {8},
      number = {5},
      pages = {127-138},
      doi = {10.11648/j.jfns.20200805.12},
      url = {https://doi.org/10.11648/j.jfns.20200805.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20200805.12},
      abstract = {Use of dietary supplements like multivitamins/multiminerals (MVMM) and antioxidant nutrients, is a potentially safe and cost-effective alternative to medications. Dietary supplements-induced health promotion is controversial among available studies, and vast majority studies were done with individual or a subset of dietary supplements. In this study we assessed the effect of a blended supplement (CellSentials), formulated with MVMM and rich phytochemicals antioxidants, on multiple cardio-metabolic risk biomarkers. We recruited 56 subjects (age: 58.8 ± 1.6) with over one year consumption of blended supplements. Common cardio-metabolic risk biomarkers were measured, including systolic and diastolic blood pressure (SBP and DBP), plasma glucose (Glu), total cholesterol (TC), triglycerides (TGs), high-density cholesterol (HDL-C)), low-density cholesterol (LDL-C), TC: HDL ratio, oxidative stress markers gamma-glutamyltransferase (GGT), and inflammation markers white blood cell (WBC) count, and C-reactive protein (CRP). They were compared to the age, gender and race-matched Non-Users from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 (n=769, mean age: 55.6 ± 0.5) by multiple linear and logistic regression analyses. Blended supplements users had significantly lower levels of Glucose (p< 0.001), TGs (p<0.001), and TC: HDL-C ratio (p<0.001), higher level of HDL-C (p=0.008) as well as lower levels of GGT (p=0.002), CRP (p=0.007) and WBC (p=0.002) than NHANES controls. There were no significant differences in SBP, DBP, TC, LDL-C. Correspondingly, blended supplements users had significantly reduced risks of elevated glucose (OR, 0.21; 95% CI, 0.07 – 0.61), ratio of TC: HDL-C (OR, 0.08; 95% CI, 0.02 – 0.31), TGs levels (OR, 0.07; 95% CI, 0.01 – 0.4), and low HDL-C (OR, 0.23; 95%CI, 0.06 – 0.88). These results demonstrated that blended supplement users had healthier pattern in cardio-metabolic biomarkers than control.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study
    AU  - Huifeng Jin
    AU  - Rolando Lorenzo Maddela
    AU  - Robert Andrew Sinnott
    Y1  - 2020/10/30
    PY  - 2020
    N1  - https://doi.org/10.11648/j.jfns.20200805.12
    DO  - 10.11648/j.jfns.20200805.12
    T2  - Journal of Food and Nutrition Sciences
    JF  - Journal of Food and Nutrition Sciences
    JO  - Journal of Food and Nutrition Sciences
    SP  - 127
    EP  - 138
    PB  - Science Publishing Group
    SN  - 2330-7293
    UR  - https://doi.org/10.11648/j.jfns.20200805.12
    AB  - Use of dietary supplements like multivitamins/multiminerals (MVMM) and antioxidant nutrients, is a potentially safe and cost-effective alternative to medications. Dietary supplements-induced health promotion is controversial among available studies, and vast majority studies were done with individual or a subset of dietary supplements. In this study we assessed the effect of a blended supplement (CellSentials), formulated with MVMM and rich phytochemicals antioxidants, on multiple cardio-metabolic risk biomarkers. We recruited 56 subjects (age: 58.8 ± 1.6) with over one year consumption of blended supplements. Common cardio-metabolic risk biomarkers were measured, including systolic and diastolic blood pressure (SBP and DBP), plasma glucose (Glu), total cholesterol (TC), triglycerides (TGs), high-density cholesterol (HDL-C)), low-density cholesterol (LDL-C), TC: HDL ratio, oxidative stress markers gamma-glutamyltransferase (GGT), and inflammation markers white blood cell (WBC) count, and C-reactive protein (CRP). They were compared to the age, gender and race-matched Non-Users from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 (n=769, mean age: 55.6 ± 0.5) by multiple linear and logistic regression analyses. Blended supplements users had significantly lower levels of Glucose (p< 0.001), TGs (p<0.001), and TC: HDL-C ratio (p<0.001), higher level of HDL-C (p=0.008) as well as lower levels of GGT (p=0.002), CRP (p=0.007) and WBC (p=0.002) than NHANES controls. There were no significant differences in SBP, DBP, TC, LDL-C. Correspondingly, blended supplements users had significantly reduced risks of elevated glucose (OR, 0.21; 95% CI, 0.07 – 0.61), ratio of TC: HDL-C (OR, 0.08; 95% CI, 0.02 – 0.31), TGs levels (OR, 0.07; 95% CI, 0.01 – 0.4), and low HDL-C (OR, 0.23; 95%CI, 0.06 – 0.88). These results demonstrated that blended supplement users had healthier pattern in cardio-metabolic biomarkers than control.
    VL  - 8
    IS  - 5
    ER  - 

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Author Information
  • Research and Development, USANA Health Sciences, Inc., Salt Lake City, USA

  • Research and Development, USANA Health Sciences, Inc., Salt Lake City, USA

  • Research and Development, USANA Health Sciences, Inc., Salt Lake City, USA

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